Sheffield’s championship team was named as the young roster on Wednesday, with Cole McGhee and George Brown making their debuts.
Will Grainger, 16, is on the bench.
Sheffield Wednesday Wednesday: Hovas, Semira, McGee, Weaver, Otegbayo, Johnson, Fusire, Shipston, Thornton, J Lowe, Brown
Submarines: Stretch, Palmer, Emery, Evers, Bannan, Grainger, McNeill, Ugbo
Leeds made nine changes to the side of Arsenal from a 5-0 loss over the weekend.
Ilia Gruev and Joel Piroe are the only two that have kept their place in 11.
Leeds 12: Dalo, Longstaff, Piro, Aaronson, Enmecha, Björ, Okafor, Harrison, Harrison, Bernabeuf, Byram, Grove.
Submarines: Perri, Bogle, Gudmundsson, Rodon, James, Calvert-Lewin, Stach, Gnonto, Gray.